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CS-W001157 4
Total: USD 88.00

3,5-Bis(trifluoromethyl)-2(1H)-pyridinone

  • CAS No. 38609-76-6

  • Cat. No. CS-0119438
  • Purity≥96%
  • MDL No.MFCD28802532

*For research and further manufacturing use only, not for direct human use.

3,5-Bis(trifluoromethyl)-2(1H)-pyridinone|CS-0119438

Structure of 38609-76-6

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General Information

  • CAS No. 38609-76-6
  • Cat. No. CS-0119438
  • Purity ≥96%
  • MDL No. MFCD28802532
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₃F₆NO
  • Molecular Weight 231.10
  • Synonym(s) 3,5-Bis(trifluoromethyl)pyridin-2(1H)-one
  • SMILES O=C1C(C(F)(F)F)=CC(C(F)(F)F)=CN1

Application

3,5-Bis(trifluoromethyl)pyridin-2-ol serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles through palladium-catalyzed cross-coupling and direct arylation reactions. Its trifluoromethyl groups enhance metabolic stability and lipophilicity, while the phenolic hydroxyl group provides a handle for derivatization. The compound exhibits excellent bench stability and facilitates efficient purification, making it well-suited for scalable synthesis and API development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

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Computational Chemistry Data

  • TPSA   33.12
  • LogP   2.8248
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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