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CS-W001157 4
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1,3-dibromo-2-methoxybenzene

  • CAS No. 38603-09-7

  • Cat. No. CS-0150529
  • Purity≥98%
  • MDL No.MFCD00093270

*For research and further manufacturing use only, not for direct human use.

1,3-dibromo-2-methoxybenzene|CS-0150529

Structure of 38603-09-7

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General Information

  • CAS No. 38603-09-7
  • Cat. No. CS-0150529
  • Purity ≥98%
  • MDL No. MFCD00093270
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆Br₂O
  • Molecular Weight 265.93
  • Synonym(s) 2,6-Dibromo-1-methoxybenzene
  • SMILES COC1=C(C=CC=C1Br)Br

Description

1,3-Dibromo-2-methoxybenzene features a methoxy-substituted benzene core with bromine atoms at the 1 and 3 positions, enabling selective cross-coupling reactions. This electron-rich scaffold integrates readily into complex molecular architectures under standard palladium-catalyzed conditions, offering high functional group tolerance and stability during process development workflows.

Application

1,3-Dibromo-2-methoxybenzene serves as a versatile ortho-directed building block for the synthesis of substituted aromatic systems. The methoxy group enhances regioselectivity in electrophilic substitution and stabilizes intermediates during palladium-catalyzed cross-coupling reactions. Its bench-stable crystalline form facilitates handling and purification, while the bromine substituents enable efficient Suzuki, Stille, and Negishi couplings, making it a reliable scaffold for constructing complex heterocycles and functionalized aryl architectures in medicinal chemistry and materials science.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   9.23
  • LogP   3.2202
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   1

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