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CS-W001157 4
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5-Thiazolemethanol

  • CAS No. 38585-74-9

  • Cat. No. CS-W013621
  • Purity≥98%
  • MDL No.MFCD04115732

*For research and further manufacturing use only, not for direct human use.

5-Thiazolemethanol|CS-W013621

Structure of 38585-74-9

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General Information

  • CAS No. 38585-74-9
  • Cat. No. CS-W013621
  • Purity ≥98%
  • MDL No. MFCD04115732
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₅NOS
  • Molecular Weight 115.16
  • Synonym(s) None
  • SMILES C1=C(SC=N1)CO

Description

5-Thiazolemethanol features a reactive hydroxymethyl group attached to a heteroaromatic thiazole ring, enabling direct functionalization in synthetic transformations. The molecule exhibits good solubility in polar solvents and stability under standard bench conditions, facilitating its use in medicinal chemistry and materials synthesis.

Application

5-Thiazolemethanol serves as a versatile building block in synthetic organic chemistry, enabling the construction of thiazole-based heterocycles and functionalized scaffolds. Its hydroxymethyl group facilitates direct derivatization via oxidation, protection, or coupling reactions, while the thiazole ring offers robust stability and compatibility with diverse reaction conditions. This compound functions effectively in medicinal chemistry campaigns and process development due to its bench stability and ease of purification.

Synthesis

  • Route1

    References

    • Abbott Laboratories Patent: US5455351 A1, 1995 ; US 5455351 A
  • Route2

    References

    • TIBOTEC PHARMACEUTICALS LTD Patent: WO2003/97616 A1, 2003 ; Location in patent: Page/Page column 26 ; WO 03/097616 A1
  • Route3

    References

    • Kerdesky; Seif Synthetic Communications, 1995 , vol. 25, # 24 p. 4081 - 4086

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 1760
Class : 8
Packing Group : Ⅲ
Hazard Statements : H318
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   33.12
  • LogP   0.6354
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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