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CS-W001157 4
Total: USD 88.00

Iodocyclobutane

  • CAS No. 38557-29-8

  • Cat. No. CS-0131037
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Iodocyclobutane|CS-0131037

Structure of 38557-29-8

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General Information

  • CAS No. 38557-29-8
  • Cat. No. CS-0131037
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₇I
  • Molecular Weight 182.00
  • Synonym(s) Cyclobutane,iodo
  • SMILES IC1CCC1

Description

Iodocyclobutane is a strained-ring organoiodide featuring a reactive cyclobutane scaffold that enables facile C–I bond cleavage under mild conditions. This high ring strain drives efficient functionalization in transition-metal-catalyzed cross-coupling reactions, offering rapid access to complex cyclic architectures. The molecule demonstrates excellent stability under standard handling protocols and integrates seamlessly into synthetic sequences requiring selective alkylation or radical-mediated transformations.

Application

Iodocyclobutane serves as a versatile cyclobutyl transfer reagent in synthetic organic chemistry, enabling efficient C–C and C–heteroatom bond formation via transition-metal-catalyzed cross-coupling. Its strained ring system enhances reactivity while maintaining bench stability under inert conditions. The iodide moiety facilitates selective functionalization, making it valuable for constructing cyclic scaffolds in medicinal chemistry and materials science applications.

Synthesis

  • Route1
    • null|null
      4399-47-7
    • ~35%
    • In-stock
      Iodocyclobutane|CS-0131037
      38557-29-8

    References

    • Abramova, N. M.; Zotova, S. V.; Nesmeyanova, O. A. Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1982 , vol. 31, # 5 p. 961 - 964 Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1982 , # 5 p. 1080 - 1083
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    References

    • Abramova, N. M.; Zotova, S. V.; Nesmeyanova, O. A. Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1982 , vol. 31, # 5 p. 961 - 964 Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1982 , # 5 p. 1080 - 1083
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    References

    • Wurrey, C. J.; Yeh, Y. Y.; Krishnamoorthi, R.; Berry, R. J.; DeWitt, J. E.; Kalasinsky, V. F. Journal of Physical Chemistry, 1984 , vol. 88, # 18 p. 4059 - 4063

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02,GHS07
Signal Word : Danger
UN#: 1993
Class : 3
Packing Group : Ⅲ
Hazard Statements : H225-H315-H319
Precautionary Statements : P210-P233-P240-P241-P242-P243-P264-P280-P362+P364-P370+P378-P501

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Computational Chemistry Data

  • TPSA   0
  • LogP   1.9739
  • H_Acceptors   0
  • H_Donors   0
  • Rotatable_Bonds   0

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