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CS-W001157 4
Total: USD 88.00

1-(4-Iodophenyl)-2-piperidinone

  • CAS No. 385425-15-0

  • Cat. No. CS-M2607
  • Purity≥98%
  • MDL No.MFCD04037128

*For research and further manufacturing use only, not for direct human use.

1-(4-Iodophenyl)-2-piperidinone|CS-M2607

Structure of 385425-15-0

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General Information

  • CAS No. 385425-15-0
  • Cat. No. CS-M2607
  • Purity ≥98%
  • MDL No. MFCD04037128
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₂INO
  • Molecular Weight 301.13
  • Synonym(s) 1-(4-Iodophenyl)piperidin-2-one
  • SMILES O=C1N(CCCC1)C(C=C2)=CC=C2I

Description

1-(4-Iodophenyl)-2-piperidinone features a iodinated aromatic ring fused to a piperidinone scaffold, enabling direct coupling in cross-coupling reactions. The electron-deficient aryl iodide serves as a reactive handle for palladium-catalyzed transformations, while the cyclic amide offers structural rigidity and enhanced solubility. This compound integrates readily into pharmaceutical intermediates and functional materials.

Application

1-(4-Iodophenyl)-2-piperidinone serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions for the construction of biaryl scaffolds. The iodide group provides high reactivity in Suzuki, Stille, and Negishi couplings, while the piperidinone core offers a well-defined nitrogen-containing heterocyclic framework with favorable solubility and functional group tolerance. Its bench-stable crystalline form facilitates handling and purification, making it suitable for scalable synthesis of pharmaceutical intermediates.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   20.31
  • LogP   2.8081
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   1

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