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CS-W001157 4
Total: USD 88.00

2-Chloro-6-methoxyphenylboronic acid

  • CAS No. 385370-80-9

  • Cat. No. CS-W016885
  • Purity≥98%
  • MDL No.MFCD04039878

*For research and further manufacturing use only, not for direct human use.

2-Chloro-6-methoxyphenylboronic acid|CS-W016885

Structure of 385370-80-9

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General Information

  • CAS No. 385370-80-9
  • Cat. No. CS-W016885
  • Purity ≥98%
  • MDL No. MFCD04039878
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₈BClO₃
  • Molecular Weight 186.40
  • Synonym(s) 2-Chloro-6-methoxybenzeneboronic Acid (contains varying amounts of Anhydride)
  • SMILES COC1=CC=CC(Cl)=C1B(O)O

Description

2-Chloro-6-methoxyphenylboronic acid features a boronic acid group flanked by electron-withdrawing chlorine and electron-donating methoxy substituents, enabling efficient Suzuki-Miyaura coupling under mild conditions. This bench-stable reagent integrates readily into complex molecular architectures, particularly in pharmaceutical and agrochemical synthesis where regioselective C–C bond formation is critical.

Application

2-Chloro-6-methoxyphenylboronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling efficient C–C bond formation under mild conditions. The ortho-chloro substituent provides compatibility with subsequent palladium-catalyzed transformations, while the methoxy group enhances solubility and electronic modulation. Bench-stable and readily purified by recrystallization, it facilitates the construction of substituted biaryl scaffolds relevant to pharmaceutical and agrochemical synthesis.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   49.69
  • LogP   0.0284
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   2

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