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CS-W001157 4
Total: USD 88.00

3-Fluoro-2-nitrophenol

  • CAS No. 385-01-3

  • Cat. No. CS-W007764
  • Purity≥98%
  • MDL No.MFCD07368753
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

3-Fluoro-2-nitrophenol|CS-W007764

Structure of 385-01-3

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Description

3-Fluoro-2-nitrophenol features a fluorine atom ortho to a nitro group on a phenolic scaffold, creating a strongly electron-deficient aromatic system. This configuration enhances reactivity in nucleophilic substitution and enables selective functionalization under mild conditions. The compound exhibits bench-stable handling characteristics and integrates readily into synthetic routes targeting bioactive heterocycles and advanced pharmaceutical intermediates.

Application

3-Fluoro-2-nitrophenol serves as a versatile building block in synthetic organic chemistry, enabling direct functionalization of electron-deficient aromatic systems. Its ortho-nitro and fluoro substituents facilitate subsequent coupling reactions, including palladium-catalyzed cross-couplings and nucleophilic aromatic substitutions. The compound exhibits good bench stability and is readily purified by recrystallization, making it suitable for use in the synthesis of heterocyclic scaffolds and pharmaceutical intermediates.

General Information

  • CAS No. 385-01-3
  • Cat. No. CS-W007764
  • Purity ≥98%
  • MDL No. MFCD07368753
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄FNO₃
  • Molecular Weight 157.10
  • Synonym(s) 2-nitro-3-fluorophenol
  • SMILES FC1=C([N+]([O-])=O)C(O)=CC=C1

Computational Chemistry Data

  • TPSA   63.37
  • LogP   1.4395
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07,GHS09
Signal Word : Danger
UN#: 3077
Class : 9
Packing Group :
Hazard Statements : H302-H315-H317-H318-H410
Precautionary Statements : P261-P264-P270-P272-P273-P280-P302+P352-P330-P362+P364-P391-P501

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