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CS-W001157 4
Total: USD 88.00

(2-Bromophenylethynyl)trimethylsilane

  • CAS No. 38274-16-7

  • Cat. No. CS-0204562
  • Purity≥98%
  • MDL No.MFCD01321391

*For research and further manufacturing use only, not for direct human use.

(2-Bromophenylethynyl)trimethylsilane|CS-0204562

Structure of 38274-16-7

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General Information

  • CAS No. 38274-16-7
  • Cat. No. CS-0204562
  • Purity ≥98%
  • MDL No. MFCD01321391
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₃BrSi
  • Molecular Weight 253.21
  • Synonym(s) 2-(2-bromophenyl)ethynyl-trimethylsilane
  • SMILES BrC=1C=CC=CC1C#C[Si](C)(C)C

Description

This boronate moiety integrates a trimethylsilyl-protected alkyne for stable, selective coupling in cross-coupling reactions. The ortho-bromophenyl group enables sequential functionalization, while the silyl-protected acetylene offers enhanced stability and moisture tolerance under standard conditions.

Application

(2-Bromophenylethynyl)trimethylsilane serves as a versatile building block for palladium-catalyzed cross-coupling reactions, enabling efficient access to substituted aryl alkynes. Its trimethylsilyl group enhances stability and facilitates mild deprotection, while the bromoaryl functionality supports robust coupling with diverse nucleophiles. The molecule exhibits excellent bench stability, functional group tolerance, and compatibility with standard reaction conditions, making it ideal for constructing complex scaffolds in medicinal chemistry and materials science workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362

Quality Control

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Computational Chemistry Data

  • TPSA   0
  • LogP   3.678
  • H_Acceptors   0
  • H_Donors   0
  • Rotatable_Bonds   0

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