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Structure of 3817-05-8
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2-(Chloromethyl)quinazolin-4(3H)-one features a reactive chloromethyl group attached to the quinazolinone scaffold, enabling site-specific conjugation in medicinal chemistry. This electrophilic handle facilitates efficient coupling with nucleophiles, including amines and thiols, under mild conditions. The molecule exhibits excellent bench stability and solubility in common organic solvents, streamlining integration into synthetic workflows for targeted probe development and drug discovery applications.
2-(Chloromethyl)quinazolin-4(3H)-one serves as a versatile building block for medicinal chemistry and heterocyclic synthesis, enabling efficient C–C and C–N bond formation via nucleophilic substitution. The chloromethyl group exhibits high reactivity toward amines, thiols, and carbon nucleophiles under mild conditions, facilitating rapid diversification of the quinazolinone scaffold. Its bench-stable nature and compatibility with common functional groups make it ideal for parallel library synthesis and API development workflows.
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GHS Pictogram :
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GHS No : GHS05,GHS07
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Signal Word : Danger
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UN#: 3261
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Class : 8
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Packing Group : Ⅱ
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Hazard Statements : H302-H314
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Precautionary Statements : P260-P264-P270-P280-P301+P330+P331-P304+P340-P363-P405-P501
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Lot numbers can be found on the outside label of a product: