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CS-W001157 4
Total: USD 88.00

2-(Methylsulfonylamino)benzeneboronic acid pinacol ester

  • CAS No. 380430-60-4

  • Cat. No. CS-W004042
  • Purity≥97%
  • MDL No.MFCD02179479

*For research and further manufacturing use only, not for direct human use.

2-(Methylsulfonylamino)benzeneboronic acid pinacol ester|CS-W004042

Structure of 380430-60-4

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General Information

  • CAS No. 380430-60-4
  • Cat. No. CS-W004042
  • Purity ≥97%
  • MDL No. MFCD02179479
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₂₀BNO₄S
  • Molecular Weight 297.18
  • Synonym(s) N-(2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanesulfonamide
  • SMILES CS(=O)(=O)Nc1ccccc1B1OC(C(O1)(C)C)(C)C

Description

This boronate ester features a methylsulfonylamino-substituted aryl group, offering enhanced solubility and stability in aqueous and polar solvents. The pinacol protection group enables reliable handling and compatibility with Suzuki-Miyaura cross-coupling protocols under standard conditions.

Application

2-(Methylsulfonylamino)benzeneboronic acid pinacol ester serves as a stable, bench-friendly boronate building block for Suzuki-Miyaura cross-coupling reactions. The methylsulfonylamino group provides excellent functional group tolerance and enhances solubility in polar solvents, facilitating efficient coupling with aryl and heteroaryl halides. Its pinacol ester moiety ensures improved stability during storage and handling, enabling reliable use in multi-step synthesis of complex pharmaceutical intermediates and functionalized biaryls.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   64.63
  • LogP   1.3573
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   3

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