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CS-W001157 4
Total: USD 88.00

4-Aminocinnoline-3-carboxamide

  • CAS No. 38024-35-0

  • Cat. No. CS-0664199
  • Purity≥98%
  • MDL No.MFCD03056454

*For research and further manufacturing use only, not for direct human use.

4-Aminocinnoline-3-carboxamide|CS-0664199

Structure of 38024-35-0

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General Information

  • CAS No. 38024-35-0
  • Cat. No. CS-0664199
  • Purity ≥98%
  • MDL No. MFCD03056454
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₈N₄O
  • Molecular Weight 188.19
  • Synonym(s) None
  • SMILES C1=CC=C2C(=C1)C(=C(N=N2)C(=O)N)N

Description

4-Aminocinnoline-3-carboxamide features a fused heterocyclic core with strategically positioned amino and carboxamide groups, enabling direct integration into kinase inhibitor scaffolds. This electron-rich framework supports hydrogen bonding and π-stacking interactions in target binding pockets, enhancing affinity and selectivity in medicinal chemistry applications.

Application

4-Aminocinnoline-3-carboxamide serves as a versatile heterocyclic building block for medicinal chemistry and catalytic process development. Its dual amine and carboxamide functionalities enable diverse coupling reactions, including amide bond formation and transition-metal-catalyzed cross-couplings. The scaffold exhibits good bench stability and facilitates purification via standard chromatographic methods, supporting its use in iterative synthesis of kinase inhibitors and other bioactive molecules.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   94.89
  • LogP   0.3109
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   1

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