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Dexamethasone impurity 3

  • CAS No. 37927-01-8

  • Cat. No. CS-0085351
  • Purity≥98%
  • MDL No.MFCD12031457

*For research and further manufacturing use only, not for direct human use.

Dexamethasone impurity 3|CS-0085351

Structure of 37927-01-8

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General Information

  • CAS No. 37927-01-8
  • Cat. No. CS-0085351
  • Purity ≥98%
  • MDL No. MFCD12031457
  • Storage Sealed in dry,2-8℃
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₁H₂₇FO₅
  • Molecular Weight 378.43
  • Synonym(s) None
  • SMILES O=C1C=C[C@@]2(C)C(CC[C@]3([H])[C@]2(F)[C@@H](O)C[C@@]4(C)[C@@]3([H])C[C@@H](C)[C@]4(O)C(O)=O)=C1

Synthesis

  • Route1

    References

    • PFIZER LIMITED; GLOSSOP, Paul Alan; MILLAN, David Simon; PRICE, David Anthony Patent: WO2010/136940 A1, 2010 ; Location in patent: Page/Page column 64 ; WO 2010/136940 A1
  • Route2
    • Dexamethasone Impurity 66|CS-1003500
      2964-79-6
    • ~%
    • Dexamethasone impurity 3|CS-0085351
      37927-01-8

    References

    • Edmonds, John S.; Morita, Masatoshi; Turner, Peter; Skelton, Brian W.; White, Allan H. Steroids, 2006 , vol. 71, # 1 p. 34 - 41

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS08
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H361-H373
Precautionary Statements : P260-P280-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   94.83
  • LogP   2.4189
  • H_Acceptors   4
  • H_Donors   3
  • Rotatable_Bonds   1

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