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CS-W001157 4
Total: USD 88.00

1-(3-Methoxypyridin-2-yl)ethanone

  • CAS No. 379227-03-9

  • Cat. No. CS-W021223
  • Purity≥98%
  • MDL No.MFCD18256469

*For research and further manufacturing use only, not for direct human use.

1-(3-Methoxypyridin-2-yl)ethanone|CS-W021223

Structure of 379227-03-9

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General Information

  • CAS No. 379227-03-9
  • Cat. No. CS-W021223
  • Purity ≥98%
  • MDL No. MFCD18256469
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₉NO₂
  • Molecular Weight 151.16
  • Synonym(s) Ethanone, 1-(3-methoxy-2-pyridinyl)- (9CI)
  • SMILES COC1=CC=CN=C1C(C)=O

Description

1-(3-Methoxypyridin-2-yl)ethanone features a pyridine ring bearing a methoxy group at the 3-position and a ketone functionality at the 2-position, delivering a robust, bench-stable scaffold for synthetic diversification. The electron-deficient heterocycle pairs effectively with nucleophilic reagents, enabling efficient coupling in transition-metal-catalyzed transformations.

Application

1-(3-Methoxypyridin-2-yl)ethanone serves as a versatile building block for heterocyclic synthesis, enabling efficient access to pyridine-based pharmacophores. Its ketone functionality facilitates nucleophilic addition, enolization, and coupling reactions under standard conditions. The 3-methoxypyridinyl moiety provides moderate electron-withdrawing character and enhanced solubility, supporting broad functional group tolerance and ease of purification in multi-step sequences.

Synthesis

  • Route1
    • 1-(3-Methoxypyridin-2-yl)ethan-1-ol|CS-1248562
      81376-85-4
    • ~%
    • In-stock
      1-(3-Methoxypyridin-2-yl)ethanone|CS-W021223
      379227-03-9

    References

    • Taisho Pharmaceutical Co., Ltd.; Meiji Seika Kaisha, Ltd. Patent: EP2287173 A1, 2011 ; Location in patent: Page/Page column 38 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   39.19
  • LogP   1.2928
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   2

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