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CS-W001157 4
Total: USD 88.00

O-[(3-Pyridyl)methyl]hydroxylamine

  • CAS No. 37832-20-5

  • Cat. No. CS-0156816
  • Molecule weight124.14
  • Purity≥97%
  • MDL No.MFCD13175304

*For research and further manufacturing use only, not for direct human use.

O-[(3-Pyridyl)methyl]hydroxylamine|CS-0156816

Structure of 37832-20-5

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General Information

  • CAS No. 37832-20-5
  • Cat. No. CS-0156816
  • Purity ≥97%
  • MDL No. MFCD13175304
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₈N₂O
  • Molecular Weight 124.14
  • Synonym(s) O-[(pyridin-3-yl)methyl]hydroxylamine
  • SMILES C1=CC(=CN=C1)CON

Description

O-[(3-Pyridyl)methyl]hydroxylamine features a pyridyl-bearing hydroxylamine group that enables selective coupling reactions in synthetic chemistry. This bench-stable reagent integrates readily into nitrogen-functionalized scaffolds, offering enhanced solubility and reactivity under mild conditions.

Application

O-[(3-Pyridyl)methyl]hydroxylamine serves as a versatile building block for the synthesis of pyridine-containing heterocycles and bioactive molecules. Its hydroxylamine functionality enables efficient oxime formation, while the 3-pyridyl group provides enhanced solubility and compatibility with transition metal-catalyzed transformations. The compound exhibits good bench stability and facilitates straightforward purification, making it well-suited for iterative synthetic sequences in medicinal chemistry and process development.

Synthesis

  • Route1
    • 2-(Pyridin-3-ylmethoxy)isoindoline-1,3-dione|CS-0161603
      30777-95-8
    • ~%
    • In-stock
      O-[(3-Pyridyl)methyl]hydroxylamine|CS-0156816
      37832-20-5

    References

    • Huang, Jia-Xing; Jia, Yue-Mei; Liang, Xiao-Mei; Zhu, Wei-Juan; Zhang, Jian-Jun; Dong, Yan-Hong; Yuan, Hui-Zu; Qi, Shu-Hua; Wu, Jin-Ping; Chen, Fu-Heng; Wang, Dao-Quan Journal of Agricultural and Food Chemistry, 2007 , vol. 55, # 26 p. 10857 - 10863
  • Route2

    References

    • Gao, Jinshan; Thomas, Daniel A.; Sohn, Chang Ho; Beauchamp Journal of the American Chemical Society, 2013 , vol. 135, # 29 p. 10684 - 10692

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02,GHS07
Signal Word : Danger
UN#: 1993
Class : 3
Packing Group : Ⅱ
Hazard Statements : H225-H315-H319
Precautionary Statements : P210-P233-P240-P241-P242-P243-P264-P280-P362-P370+P378-P501

Quality Control

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Computational Chemistry Data

  • TPSA   48.14
  • LogP   0.4719
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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