(R)-3-Aminobutanoic acid

Name: (R)-3-Aminobutanoic acid
Brand: ChemScene
Availability: InStock
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CAS No. 3775-73-3
Cat. No. CS-W005235
Purity≥98%
MDL No.MFCD00211284

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 3775-73-3

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General Information

CAS No. 3775-73-3
Cat. No. CS-W005235
Purity ≥98%
MDL No. MFCD00211284
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₄H₉NO₂
Molecular Weight 103.12
Synonym(s) L-3-Abu-OH
SMILES C[C@@H](N)CC(O)=O

Description

(R)-3-Aminobutanoic acid is a chiral building block featuring a stereodefined amino group at the C3 position, enabling precise incorporation into bioactive molecules. This bench-stable derivative supports asymmetric synthesis and peptide conjugation workflows with predictable stereochemical outcomes.

Application

(R)-3-Aminobutanoic acid serves as a key chiral building block for synthesizing bioactive molecules, particularly in the construction of γ-aminobutyric acid (GABA) analogs and peptidomimetics. Its well-defined stereochemistry enables reliable incorporation into complex scaffolds with minimal epimerization risk. The compound exhibits excellent bench stability, facilitates straightforward purification via crystallization or ion-exchange chromatography, and demonstrates broad functional group tolerance in standard amide coupling and reductive amination protocols.

Synthesis

Route1
- 64838-60-4
- ~92%
- In-stock
  
  3775-73-3
References
- Juaristi, Eusebio; Escalante, Jaime; Lamatsch, Bernd; Seebach, Dieter Journal of Organic Chemistry, 1992 , vol. 57, # 8 p. 2396 - 2398
Route2
- 134430-94-7
- ~69%
- In-stock
  
  3775-73-3
References
- Davies, Stephen G.; Garrido, Narciso M.; Kruchinin, Dennis; Ichihara, Osamu; Kotchie, Luke J.; Price, Paul D.; Mortimer, Anne J. Price; Russell, Angela J.; Smith, Andrew D. Tetrahedron Asymmetry, 2006 , vol. 17, # 12 p. 1793 - 1811
Route3
- 394220-59-8
- ~83%
- In-stock
  
  3775-73-3
References
- Sibi, Mukund P.; Liu, Mei Organic Letters, 2001 , vol. 3, # 26 p. 4181 - 4184

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 63.32
LogP -0.1917
H_Acceptors 2
H_Donors 2
Rotatable_Bonds 2

Other Classifications

Life Science Amino Acids and their Derivatives Alanine and derivatives

Building Blocks Functional Group Amine

Building Blocks Functional Group Carboxylic Acid

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Chemical Biology Peptide Chemistry Unnatural Amino Acid Derivatives

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Peptide Chemistry Unnatural Amino Acid Derivatives

Chemical Biology Pharmaceutical Development and Drug Discovery Research Peptide Chemistry Amino Acid Derivatives

Chemical Biology Pharmaceutical Development and Drug Discovery Research Peptide Chemistry Unnatural Amino Acid Derivatives

Biochemistry Biochemicals and Reagents Amino Acids non-Proteinogenic Amino Acids

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(R)-3-Aminobutanoic acid

CAS No. 3775-73-3

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