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Structure of 376591-95-6
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This biphenyl-based carboxylic acid features a hydroxyl group at the 2'-position and a nitro substituent at the 3'-position, creating an electron-deficient aryl system with enhanced solubility and reactivity. The ortho-hydroxy and para-nitro arrangement enables intramolecular hydrogen bonding, stabilizing reactive intermediates in transition metal-catalyzed transformations. This scaffold serves as a key building block for bioactive heterocycles and functional materials.
2'-Hydroxy-3'-nitro-[1,1'-biphenyl]-3-carboxylic acid serves as a versatile building block for the synthesis of biologically relevant biphenyl scaffolds. The ortho-hydroxyl and meta-nitro groups enable directed metalation and facilitate subsequent functionalization via cross-coupling or nitro reduction. Its stability under standard bench conditions and compatibility with common protecting group strategies make it well-suited for iterative synthetic sequences in medicinal chemistry and materials science applications.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319
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Precautionary Statements : P264-P280-P302+P352-P362+P364
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Lot numbers can be found on the outside label of a product: