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CS-W001157 4
Total: USD 88.00

4,4-Difluorocyclohexane-1-carbonyl chloride

  • CAS No. 376348-75-3

  • Cat. No. CS-0697486
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4,4-Difluorocyclohexane-1-carbonyl chloride|CS-0697486

Structure of 376348-75-3

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General Information

  • CAS No. 376348-75-3
  • Cat. No. CS-0697486
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₉ClF₂O
  • Molecular Weight 182.60
  • Synonym(s) None
  • SMILES FC1(F)CCC(CC1)C(Cl)=O

Description

4,4-Difluorocyclohexane-1-carbonyl chloride features a fluorinated cyclohexane core with a reactive acyl chloride group, enabling direct incorporation into complex molecular architectures. The geminal difluoro substitution enhances metabolic stability and modulates electronic properties, making this reagent valuable for medicinal chemistry applications requiring robust, lipophilic linkages.

Application

4,4-Difluorocyclohexane-1-carbonyl chloride serves as a versatile acylating agent for the synthesis of fluorinated carbonyl compounds. Its reactivity facilitates efficient amide and ester formation under mild conditions, with the gem-difluoro substitution enhancing metabolic stability in bioactive molecule construction. The compound exhibits good bench stability and is compatible with common functional groups, enabling straightforward purification and integration into multi-step synthetic sequences.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3265
Class : 8
Packing Group : Ⅲ
Hazard Statements : H227-H314
Precautionary Statements : P210-P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P363-P370+P378-P403+P235-P405-P501

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Computational Chemistry Data

  • TPSA   N/A
  • LogP   N/A
  • H_Acceptors   N/A
  • H_Donors   N/A
  • Rotatable_Bonds   N/A

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