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CS-W001157 4
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4-(Methoxymethyl)-1H-pyrazole

  • CAS No. 37599-34-1

  • Cat. No. CS-0051143
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-(Methoxymethyl)-1H-pyrazole|CS-0051143

Structure of 37599-34-1

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General Information

  • CAS No. 37599-34-1
  • Cat. No. CS-0051143
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₈N₂O
  • Molecular Weight 112.13
  • Synonym(s) None
  • SMILES COCC1=CNN=C1

Description

4-(Methoxymethyl)-1H-pyrazole is a bench-stable heterocyclic scaffold featuring a methoxymethyl group at the 4-position, enhancing solubility and enabling direct incorporation into bioactive molecule synthesis. This polar yet stable moiety serves as a key building block in medicinal chemistry, particularly for targeting kinase pathways and improving metabolic stability in drug candidates.

Application

4-(Methoxymethyl)-1H-pyrazole serves as a versatile building block in medicinal chemistry, enabling efficient access to functionalized pyrazole scaffolds. The methoxymethyl group offers orthogonal reactivity for selective deprotection or derivatization, while the pyrazole core provides stability and favorable pharmacophoric properties. This compound facilitates rapid diversification in target-oriented synthesis and is compatible with standard reaction conditions, including coupling and electrophilic substitution. Its bench-stable nature and ease of purification support reliable use in high-throughput screening and process development workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   37.91
  • LogP   0.5561
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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