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CS-W001157 4
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2-(Trimethylsilyl)ethyl 4-(trifluoromethylsulfonyloxy)-5,6-dihydropyridine-1(2h)-carboxylate

  • CAS No. 375854-77-6

  • Cat. No. CS-0515111
  • Purity≥98%
  • MDL No.MFCD16039327

*For research and further manufacturing use only, not for direct human use.

2-(Trimethylsilyl)ethyl 4-(trifluoromethylsulfonyloxy)-5,6-dihydropyridine-1(2h)-carboxylate|CS-0515111

Structure of 375854-77-6

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General Information

  • CAS No. 375854-77-6
  • Cat. No. CS-0515111
  • Purity ≥98%
  • MDL No. MFCD16039327
  • Storage Sealed in dry,2-8℃
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₂₀F₃NO₅SSi
  • Molecular Weight 375.44
  • Synonym(s) 2-(Trimethylsilyl)ethyl 4-(((trifluoromethyl)sulfon-yl)oxy)-5,6-dihydropyridine-1(2H)-carboxylate
  • SMILES O=C(N1CCC(OS(=O)(C(F)(F)F)=O)=CC1)OCC[Si](C)(C)C

Synthesis

  • Route1

    References

    • SANOFI; CHOI-SLEDESKI, Yong Mi; LIANG, Guyan; NIEDUZAK, Thaddeus R.; POLI, Gregory B.; SHUM, Patrick Wai-Kwok; STOKLOSA, Gregory T.; ZHAO, Zhicheng Patent: WO2011/79102 A1, 2011 ; WO 2011/079102 A1
  • Route2
    • null|null
      40064-34-4
    • ~%
    • 2-(Trimethylsilyl)ethyl 4-(trifluoromethylsulfonyloxy)-5,6-dihydropyridine-1(2h)-carboxylate|CS-0515111
      375854-77-6

    References

    • Levell, Julian; Astles, Peter; Eastwood, Paul; Cairns, Jennifer; Houille, Olivier; Aldous, Suzanne; Merriman, Gregory; Whiteley, Brian; Pribish, James; Czekaj, Mark; Liang, Guyan; Maignan, Sebastien; Guilloteau, Jean-Pierre; Dupuy, Alain; Davidson, Jane; Harrison, Trevor; Morley, Andrew; Watson, Simon; Fenton, Garry; McCarthy, Clive; Romano, Joseph; Mathew, Rose; Engers, Darren; Gardyan, Michael; Sides, Keith; Kwong, Jennifer; Tsay, Joseph; Rebello, Sam; Shen, Liduo; Wang, Jie; Luo, Yongyi; Giardino, Odessa; Lim, Heng-Keang; Smith, Keith; Pauls, Henry Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 8 p. 2859 - 2872
  • Route3

    References

    • Levell, Julian; Astles, Peter; Eastwood, Paul; Cairns, Jennifer; Houille, Olivier; Aldous, Suzanne; Merriman, Gregory; Whiteley, Brian; Pribish, James; Czekaj, Mark; Liang, Guyan; Maignan, Sebastien; Guilloteau, Jean-Pierre; Dupuy, Alain; Davidson, Jane; Harrison, Trevor; Morley, Andrew; Watson, Simon; Fenton, Garry; McCarthy, Clive; Romano, Joseph; Mathew, Rose; Engers, Darren; Gardyan, Michael; Sides, Keith; Kwong, Jennifer; Tsay, Joseph; Rebello, Sam; Shen, Liduo; Wang, Jie; Luo, Yongyi; Giardino, Odessa; Lim, Heng-Keang; Smith, Keith; Pauls, Henry Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 8 p. 2859 - 2872

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02,GHS07
Signal Word : Danger
UN#: 1993
Class : 3
Packing Group : Ⅲ
Hazard Statements : H226-H315-H319-H335
Precautionary Statements : P210-P233-P240-P241-P242-P243-P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P370+P378-P405-P501

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Computational Chemistry Data

  • TPSA   72.91
  • LogP   2.917
  • H_Acceptors   5
  • H_Donors   0
  • Rotatable_Bonds   5

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