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2-Chloroquinolin-7-ol

  • CAS No. 375358-19-3

  • Cat. No. CS-0060431
  • Purity≥95%
  • MDL No.MFCD02238180

*For research and further manufacturing use only, not for direct human use.

2-Chloroquinolin-7-ol|CS-0060431

Structure of 375358-19-3

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General Information

  • CAS No. 375358-19-3
  • Cat. No. CS-0060431
  • Purity ≥95%
  • MDL No. MFCD02238180
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₆ClNO
  • Molecular Weight 179.60
  • Synonym(s) 2-CHLORO-QUINOLIN-7-OL
  • SMILES C1=CC(=CC2=NC(=CC=C12)Cl)O

Description

2-Chloroquinolin-7-ol features a chlorine atom at the 2-position and a hydroxyl group at the 7-position of the quinoline scaffold, delivering enhanced electronic modulation and improved solubility. This configuration enables efficient incorporation into bioactive scaffolds for medicinal chemistry applications.

Application

2-Chloroquinolin-7-ol serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the C7 position via nucleophilic substitution or palladium-catalyzed coupling. Its stability under standard reaction conditions and compatibility with diverse functional groups facilitate efficient access to quinoline-based scaffolds prevalent in kinase inhibitors and antimalarial agents.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   33.12
  • LogP   2.5938
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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