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Structure of 37526-59-3
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This trifluoromethoxy-substituted sulfonamide features a highly electron-deficient aromatic ring, enhancing its utility in medicinal chemistry. The para-trifluoromethoxy group imparts strong lipophilicity and metabolic stability, while the sulfonamide moiety serves as a key hydrogen-bonding anchor in target binding. Ideal for scaffold optimization in kinase inhibitors and other bioactive molecules.
2-(Trifluoromethoxy)benzenesulfonamide serves as a versatile building block in medicinal chemistry, enabling the synthesis of sulfonamide-containing bioactive molecules. Its trifluoromethoxy group enhances metabolic stability and membrane permeability, while the sulfonamide moiety provides strong hydrogen-bonding capacity and target affinity. The compound exhibits excellent bench stability and facilitates straightforward purification, making it well-suited for high-throughput screening campaigns and API development workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: