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CS-W001157 4
Total: USD 88.00

4-Hydroxy-3-iodobenzoic acid

  • CAS No. 37470-46-5

  • Cat. No. CS-0060337
  • Purity≥97%
  • MDL No.MFCD00234263

*For research and further manufacturing use only, not for direct human use.

4-Hydroxy-3-iodobenzoic acid|CS-0060337

Structure of 37470-46-5

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General Information

  • CAS No. 37470-46-5
  • Cat. No. CS-0060337
  • Purity ≥97%
  • MDL No. MFCD00234263
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅IO₃
  • Molecular Weight 264.02
  • Synonym(s) 3-Iodo-4-hydroxybenzoicacid
  • SMILES C1=CC(=C(C=C1C(=O)O)I)O

Description

4-Hydroxy-3-iodobenzoic acid features a strategically positioned iodine atom and hydroxyl group on the aromatic ring, enabling direct functionalization in cross-coupling reactions. The carboxylic acid moiety provides a handle for amide bond formation or salt generation. This compound serves as a key intermediate in the synthesis of bioactive molecules and radiolabeled probes, offering excellent stability under standard bench conditions.

Application

4-Hydroxy-3-iodobenzoic acid serves as a versatile building block for palladium-catalyzed cross-coupling reactions, enabling efficient access to substituted phenolic scaffolds. The ortho-iodo and hydroxyl groups provide orthogonal reactivity for sequential functionalization, while the carboxylic acid facilitates derivatization or conjugation. Its bench-stable crystalline form simplifies handling and purification in synthetic workflows.

Synthesis

  • Route1
    • 4-Hydroxybenzoic acid  Cetirizine Impurity|CS-0167040
      99-96-7
    • ~99%
    • In-stock
      4-Hydroxy-3-iodobenzoic acid|CS-0060337
      37470-46-5

    References

    • Akhlaghinia, Batool; Rahmani, Marzieh Journal of the Brazilian Chemical Society, 2010 , vol. 21, # 1 p. 3 - 6
  • Route2

    References

    • KONINKLIJKE PHILIPS ELECTRONICS N.V. Patent: WO2007/110811 A2, 2007 ; Location in patent: Page/Page column 23 ;
  • Route3

    References

    • Mitsubishi Gas Chemical Company, Inc. Patent: EP2199271 A1, 2010 ; Location in patent: Page/Page column 6 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   57.53
  • LogP   1.695
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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