5-Bromo-3,4-dimethylpyridin-2-amine

Name: 5-Bromo-3,4-dimethylpyridin-2-amine
Brand: ChemScene
Availability: InStock
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CAS No. 374537-97-0
Cat. No. CS-W015564
Purity≥95%
MDL No.MFCD02093947

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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5-Bromo-3,4-dimethylpyridin-2-amine|CS-W015564

Structure of 374537-97-0

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Description

5-Bromo-3,4-dimethylpyridin-2-amine features a brominated pyridine core with two methyl groups at the 3- and 4-positions, enhancing electron density and steric profile. This configuration enables efficient coupling in transition-metal-catalyzed reactions, particularly in Pd-mediated cross-couplings. The compound exhibits bench-stable handling characteristics and integrates readily into complex heterocyclic architectures used in medicinal chemistry and materials science.

Application

5-Bromo-3,4-dimethylpyridin-2-amine serves as a versatile building block in medicinal chemistry and catalytic cross-coupling reactions. The bromine atom enables reliable Suzuki, Stille, and Negishi couplings, while the pyridin-2-amine functionality offers orthogonal reactivity for further derivatization. Bench-stable and readily purified, it facilitates efficient access to substituted heterocycles and API scaffolds under standard reaction conditions.

General Information

CAS No. 374537-97-0
Cat. No. CS-W015564
Purity ≥95%
MDL No. MFCD02093947
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₉BrN₂
Molecular Weight 201.06
Synonym(s) 5-Bromo-3,4-dimethyl-2-pyridinamine
SMILES NC1=NC=C(Br)C(C)=C1C

Computational Chemistry Data

TPSA 38.91
LogP 2.04314
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 0

Safety Information

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GHS Pictogram :	GHS No : GHS06
Signal Word : Danger	UN#: 2811
Class : 6.1	Packing Group : Ⅲ
Hazard Statements : H302+H312+H332-H315-H319-H335
Precautionary Statements : P264-P270-P330-P405-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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5-Bromo-3,4-dimethylpyridin-2-amine

CAS No. 374537-97-0

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