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Sodium 5-hydroxypentanoate

  • CAS No. 37435-69-1

  • Cat. No. CS-0047732
  • Molecule weight141.12
  • Purity≥97%
  • MDL No.MFCD22192345

*For research and further manufacturing use only, not for direct human use.

Sodium 5-hydroxypentanoate|CS-0047732

Structure of 37435-69-1

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General Information

  • CAS No. 37435-69-1
  • Cat. No. CS-0047732
  • Purity ≥97%
  • MDL No. MFCD22192345
  • Storage 4°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₁₀NaO₃
  • Molecular Weight 141.12
  • Synonym(s) 5-Hydroxypentanoic Acid Sodium Salt
  • SMILES [Na].O=C(O)CCCCO

Description

Sodium 5-hydroxypentanoate is a water-soluble salt featuring a hydroxyl-functionalized five-carbon chain. This structure enables its use in bioconjugation and polymer synthesis, where the hydroxyl group provides a reactive handle for derivatization. The sodium counterion enhances solubility and stability under physiological conditions.

Application

Sodium 5-hydroxypentanoate serves as a versatile building block in synthetic organic chemistry, enabling efficient access to γ-hydroxy carboxylates and related heterocyclic scaffolds. Its hydroxyl and carboxylate functionalities offer orthogonal reactivity for selective derivatization, including esterification, ether formation, and cyclization reactions. The salt form enhances solubility and stability in aqueous and polar organic media, facilitating handling and purification in multi-step syntheses. This compound functions reliably in standard bench-scale transformations, supporting applications in medicinal chemistry and materials science.

Synthesis

  • Route1

    References

    • Takashima, Yoshinori; Osaki, Motofumi; Harada, Akira Journal of the American Chemical Society, 2004 , vol. 126, # 42 p. 13588 - 13589
  • Route2

    References

    • Bhavaraju, Sai Patent: US2012/123168 A1, 2012 ; Location in patent: Page/Page column Sheet 7 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   46.53
  • LogP   -0.2243
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   4

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