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CS-W001157 4
Total: USD 88.00

4-Hydroxyisobenzofuran-1,3-dione

  • CAS No. 37418-88-5

  • Cat. No. CS-W005592
  • Purity≥96%
  • MDL No.MFCD00011557

*For research and further manufacturing use only, not for direct human use.

4-Hydroxyisobenzofuran-1,3-dione|CS-W005592

Structure of 37418-88-5

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General Information

  • CAS No. 37418-88-5
  • Cat. No. CS-W005592
  • Purity ≥96%
  • MDL No. MFCD00011557
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₄O₄
  • Molecular Weight 164.12
  • Synonym(s) None
  • SMILES OC1=C2C(=O)OC(=O)C2=CC=C1

Description

3-Hydroxyphthalic anhydride features a strategically positioned hydroxyl group adjacent to a reactive anhydride moiety, enabling direct conjugation in polymer synthesis and bioconjugation workflows. This bifunctional architecture supports efficient derivatization under mild conditions, offering enhanced solubility and stability compared to non-hydroxylated analogs.

Application

3-Hydroxyphthalic anhydride serves as a versatile building block in synthetic organic chemistry, enabling direct access to functionalized phthalate derivatives. Its ortho-anhydride and phenolic hydroxyl groups facilitate tandem cyclizations, esterifications, and coupling reactions under mild conditions. The molecule exhibits good bench stability and ease of purification, making it well-suited for the construction of complex heterocycles and pharmaceutical intermediates in iterative synthesis workflows.

Synthesis

  • Route1
    • null|null
      135414-50-5
    • ~70%
    • In-stock
      4-Hydroxyisobenzofuran-1,3-dione|CS-W005592
      37418-88-5

    References

    • Board of Trustees of Michigan State University Patent: US2005/267307 A1, 2005 ; Location in patent: Page/Page column 4 ;
  • Route2
    • 3-Hydroxyphthalic acid|CS-0010331
      601-97-8
    • ~%
    • In-stock
      4-Hydroxyisobenzofuran-1,3-dione|CS-W005592
      37418-88-5

    References

    • Pratt; Perkins Journal of the American Chemical Society, 1918 , vol. 40, p. 230
  • Route3
    • null|null
      100921-73-1
    • ~90%
    • In-stock
      4-Hydroxyisobenzofuran-1,3-dione|CS-W005592
      37418-88-5

    References

    • Nasman Synthesis, 1985 , vol. NO. 8, p. 788 - 789

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   63.6
  • LogP   0.7028
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   0

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