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Structure of 372-16-7
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4-((Trifluoromethyl)thio)aniline features a trifluoromethylthio group positioned para to the amino functionality, imparting enhanced electron-withdrawing character and improved metabolic stability. This configuration enables efficient coupling in cross-coupling reactions and facilitates incorporation into bioactive scaffolds requiring high lipophilicity and resistance to oxidative degradation.
4-((Trifluoromethyl)thio)aniline serves as a valuable building block in medicinal chemistry, enabling the introduction of a strongly electron-withdrawing trifluoromethylthio group at the para position of an aromatic ring. Its robust bench stability and compatibility with standard coupling reactions facilitate efficient incorporation into diverse heterocyclic scaffolds and API intermediates. The functional group exhibits high tolerance to varied reaction conditions, supporting its use in multi-step syntheses requiring selective transformations.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302+H312+H332
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P501
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Lot numbers can be found on the outside label of a product: