5-Chloro-6-methylpyridin-2-amine

Name: 5-Chloro-6-methylpyridin-2-amine
Brand: ChemScene
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CAS No. 36936-23-9
Cat. No. CS-W003618
Purity≥95%
MDL No.MFCD09453335

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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5-Chloro-6-methylpyridin-2-amine|CS-W003618

Structure of 36936-23-9

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General Information

CAS No. 36936-23-9
Cat. No. CS-W003618
Purity ≥95%
MDL No. MFCD09453335
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₇ClN₂
Molecular Weight 142.59
Synonym(s) 6-Amino-3-chloro-2-picoline
SMILES NC1=NC(C)=C(Cl)C=C1

Description

5-Chloro-6-methylpyridin-2-amine features a pyridine core functionalized with chlorine and methyl groups at the 5- and 6-positions, respectively, enabling tailored electronic modulation. This electron-deficient heterocycle integrates readily into pharmaceutical scaffolds, offering enhanced metabolic stability and favorable solubility profiles for medicinal chemistry applications.

Application

5-Chloro-6-methylpyridin-2-amine serves as a versatile building block in medicinal chemistry, enabling efficient access to substituted pyridine scaffolds via palladium-catalyzed cross-coupling reactions. Its ortho-halogen and methyl groups provide orthogonal reactivity for sequential functionalization, while the amine functionality facilitates derivatization through acylation, alkylation, or imine formation. The compound exhibits good bench stability and is compatible with standard purification methods, making it well-suited for iterative synthesis campaigns in API development.

Synthesis

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- In-stock
  
  1824-81-3
- ~%
- In-stock
  
  36936-23-9
References
- State of Oregon, acting by and through The Oregon State Board of Higher Education, acting for and on behalf of The Oregon Health Sciences University and The University of Oregon, Eugene Oregon; The Regents of the University of California; ACEA Pharmaceuticals, Inc. Patent: US5620978 A1, 1997 ; US 5620978 A

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS05,GHS07
Signal Word : Danger	UN#: 1759
Class : 8	Packing Group : Ⅲ
Hazard Statements : H302-H318
Precautionary Statements : P264-P270-P280-P330-P501

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Computational Chemistry Data

TPSA 38.91
LogP 1.62562
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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5-Chloro-6-methylpyridin-2-amine

CAS No. 36936-23-9

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