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CS-W001157 4
Total: USD 88.00

1-(4-Fluoro-3-methylphenyl)ethanone

  • CAS No. 369-32-4

  • Cat. No. CS-W018095
  • Purity≥96%
  • MDL No.MFCD04972879
  • HazMat Fee +

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    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

1-(4-Fluoro-3-methylphenyl)ethanone|CS-W018095

Structure of 369-32-4

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Description

1-(4-Fluoro-3-methylphenyl)ethanone features a fluorinated aromatic ring with a methyl substituent at the meta position, paired with a ketone-functionalized ethyl side chain. This configuration imparts enhanced lipophilicity and metabolic stability, enabling its use in medicinal chemistry scaffolds. The compound serves as a key intermediate for synthesizing bioactive molecules requiring electron-deficient aryl motifs.

Application

1-(4-Fluoro-3-methylphenyl)ethanone serves as a versatile building block in medicinal chemistry, enabling efficient access to biologically relevant aryl ketones. Its fluorinated aromatic core enhances metabolic stability and modulates electronic properties, while the acetyl group facilitates downstream transformations such as reduction, nucleophilic addition, and coupling reactions. Bench-stable and readily purified by recrystallization, it functions effectively in multi-step syntheses of pharmaceutical intermediates and functionalized heterocycles.

General Information

  • CAS No. 369-32-4
  • Cat. No. CS-W018095
  • Purity ≥96%
  • MDL No. MFCD04972879
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₉FO
  • Molecular Weight 152.17
  • Synonym(s) 4'-Fluoro-3'-methylacetophenone
  • SMILES C1=C(C(=CC=C1C(=O)C)F)C

Computational Chemistry Data

  • TPSA   17.07
  • LogP   2.33672
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   1

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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