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Structure of 368-87-6
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4-Hydroxybenzenesulfonyl fluoride is a bench-stable, moisture-tolerant reagent featuring a phenolic hydroxyl group and a reactive sulfonyl fluoride moiety. This combination enables selective derivatization of nucleophiles in synthetic workflows, particularly for introducing sulfonate linkages under mild conditions. The para-hydroxyl group enhances solubility and facilitates downstream functionalization.
4-Hydroxybenzenesulfonyl fluoride serves as a versatile sulfonating agent and electrophilic sulfonyl transfer reagent, enabling efficient introduction of the (4-hydroxyphenyl)sulfonyl group into target molecules. Its bench-stable nature and compatibility with diverse functional groups facilitate straightforward incorporation into complex synthetic intermediates, particularly in the construction of sulfonamide-based pharmaceutical building blocks and heterocyclic scaffolds via nucleophilic substitution or cyclization reactions.
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GHS Pictogram :
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GHS No : GHS05
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Signal Word : Danger
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UN#: 3261
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Class : 8
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Packing Group : Ⅱ
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Hazard Statements : H302-H314-H335
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Precautionary Statements : P260-P264-P270-P271-P280-P301+P330+P331-P304+P340-P363-P405-P501
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Lot numbers can be found on the outside label of a product: