(R)-3-Amino-4,4-dimethylpentanoic acid

Name: (R)-3-Amino-4,4-dimethylpentanoic acid
Brand: ChemScene
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CAS No. 367278-49-7
Cat. No. CS-0145791
Purity≥95%
MDL No.MFCD07784062

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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(R)-3-Amino-4,4-dimethylpentanoic acid|CS-0145791

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General Information

CAS No. 367278-49-7
Cat. No. CS-0145791
Purity ≥95%
MDL No. MFCD07784062
Storage RT, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₁₅NO₂
Molecular Weight 145.20
Synonym(s) None
SMILES CC(C)(C)[C@H](N)CC(O)=O

Description

(R)-3-Amino-4,4-dimethylpentanoic acid is a chiral building block featuring a sterically hindered α-amino acid scaffold. The geminal dimethyl groups enhance metabolic stability and influence conformational rigidity, while the primary amine and carboxylic acid functionalities enable direct incorporation into peptide sequences or conjugation workflows under standard conditions.

Application

(R)-3-Amino-4,4-dimethylpentanoic acid serves as a valuable chiral building block for peptide-based drug discovery and asymmetric synthesis. Its tertiary α-carbon enhances metabolic stability, while the pendant amine and carboxylic acid enable diverse functionalization via standard coupling, acylation, and cyclization protocols. The compound exhibits excellent bench stability and facilitates efficient purification, making it well-suited for iterative synthetic workflows in medicinal chemistry and process development.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 63.32
LogP 0.8345
H_Acceptors 2
H_Donors 2
Rotatable_Bonds 2

Other Classifications

Building Blocks Functional Group Amine

Building Blocks Functional Group Carboxylic Acid

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Key Words

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(R)-3-Amino-4,4-dimethylpentanoic acid

CAS No. 367278-49-7

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