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CS-W001157 4
Total: USD 88.00

(2,3-Dihydrobenzo[b][1,4]dioxin-2-yl)methanol

  • CAS No. 3663-82-9

  • Cat. No. CS-W017870
  • Purity≥97%
  • MDL No.MFCD00006822

*For research and further manufacturing use only, not for direct human use.

(2,3-Dihydrobenzo[b][1,4]dioxin-2-yl)methanol|CS-W017870

Structure of 3663-82-9

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General Information

  • CAS No. 3663-82-9
  • Cat. No. CS-W017870
  • Purity ≥97%
  • MDL No. MFCD00006822
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₀O₃
  • Molecular Weight 166.18
  • Synonym(s) 2-Hydroxymethyl-1,4-benzodioxane
  • SMILES OCC1COC2=C(O1)C=CC=C2

Description

This bench-stable, moisture-tolerant dihydrobenzodioxin derivative features a reactive benzylic alcohol group that integrates seamlessly into synthesis workflows. Its rigid aromatic core provides structural stability while enabling selective functionalization under standard conditions.

Application

(2,3-Dihydrobenzo[b][1,4]dioxin-2-yl)methanol serves as a versatile building block in medicinal chemistry, enabling efficient access to bioactive scaffolds through standard functional group transformations. Its bench-stable dihydrobenzodioxin core exhibits excellent tolerance to diverse reaction conditions, facilitating coupling reactions and derivatization without protection. The pendant primary alcohol provides a handle for further modification, including oxidation, etherification, or incorporation into larger molecular architectures via established protocols.

Synthesis

  • Route1

    References

    • Archiv der Pharmazie, , vol. 347, # 1 p. 32 - 41
  • Route2

    References

    • European Journal of Medicinal Chemistry, , vol. 35, # 7-8 p. 663 - 676
  • Route3
    • null|null
      96-13-9
    • null|null
      120-80-9
    • ~67%
    • In-stock
      (2,3-Dihydrobenzo[b][1,4]dioxin-2-yl)methanol|CS-W017870
      3663-82-9

    References

    • European Journal of Medicinal Chemistry, , vol. 20, # 2 p. 117 - 120

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   38.69
  • LogP   0.8187
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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