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CS-W001157 4
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2-(Hydroxymethyl)-3-nitropyridine

  • CAS No. 36625-64-6

  • Cat. No. CS-0130469
  • Purity≥98%
  • MDL No.MFCD18802584

*For research and further manufacturing use only, not for direct human use.

2-(Hydroxymethyl)-3-nitropyridine|CS-0130469

Structure of 36625-64-6

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General Information

  • CAS No. 36625-64-6
  • Cat. No. CS-0130469
  • Purity ≥98%
  • MDL No. MFCD18802584
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆N₂O₃
  • Molecular Weight 154.12
  • Synonym(s) 3-nitro-2-Pyridinemethanol
  • SMILES O=[N+]([O-])C1=CC=CN=C1CO

Description

2-(Hydroxymethyl)-3-nitropyridine features a pyridine ring functionalized with a hydroxymethyl group at the 2-position and a nitro group at the 3-position, delivering enhanced solubility and reactivity. This combination enables efficient incorporation into bioconjugation workflows and synthetic intermediates requiring controlled electron-withdrawing effects.

Application

2-(Hydroxymethyl)-3-nitropyridine serves as a versatile building block for heterocyclic synthesis, enabling efficient access to functionalized pyridine derivatives. The hydroxymethyl group facilitates selective derivatization, while the nitro functionality supports subsequent reductions and coupling reactions. Its bench-stable nature and compatibility with standard protecting group strategies make it well-suited for iterative synthetic sequences in medicinal chemistry and process development.

Synthesis

  • Route1
    • (3-Nitropyridin-2-yl)methyl acetate|CS-0734575
      131747-33-6
    • ~94%
    • In-stock
      2-(Hydroxymethyl)-3-nitropyridine|CS-0130469
      36625-64-6

    References

    • Odashima, Tsugikatsu; Sakakura, Kei; Kohata, Katsunori; Ishii, Hajime Bulletin of the Chemical Society of Japan, 1993 ,  vol. 66,  # 3  p. 797 - 803

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   76.26
  • LogP   0.4821
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   2

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