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CS-W001157 4
Total: USD 88.00

4-((4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)thiophen-2-yl)methyl)morpholine

  • CAS No. 364794-85-4

  • Cat. No. CS-0161024
  • Molecule weight309.23
  • Purity≥98%
  • MDL No.MFCD11841079

*For research and further manufacturing use only, not for direct human use.

4-((4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)thiophen-2-yl)methyl)morpholine|CS-0161024

Structure of 364794-85-4

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General Information

  • CAS No. 364794-85-4
  • Cat. No. CS-0161024
  • Purity ≥98%
  • MDL No. MFCD11841079
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₅H₂₄BNO₃S
  • Molecular Weight 309.23
  • Synonym(s) 4-[[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)thiophen-2-yl]methyl]morpholine
  • SMILES CC1(C)C(C)(C)OB(C2=CSC(CN3CCOCC3)=C2)O1

Description

4-((4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)thiophen-2-yl)methyl)morpholine integrates a boronate handle with a thiophene-linked morpholine moiety, enabling efficient Suzuki-Miyaura coupling under standard conditions. This bench-stable reagent facilitates the construction of complex heterocyclic architectures in medicinal chemistry and materials synthesis.

Application

4-((4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)thiophen-2-yl)methyl)morpholine serves as a versatile boron-containing building block for Suzuki-Miyaura cross-coupling reactions. The tetramethylborolane moiety enables stable, room-temperature handling and efficient coupling with aryl halides under mild conditions. The morpholine-linked thiophene scaffold provides a polar, electron-rich motif suitable for medicinal chemistry applications, offering favorable solubility and metabolic stability in target-directed synthesis.

Safety Information

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GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H314
Precautionary Statements : P260-P264-P270-P280-P301+P330+P331-P304+P340-P330-P363-P405-P501

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Computational Chemistry Data

  • TPSA   30.93
  • LogP   1.8795
  • H_Acceptors   5
  • H_Donors   0
  • Rotatable_Bonds   3

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