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CS-W001157 4
Total: USD 88.00

H-1,2,4-Triazole-3-carboxamide

  • CAS No. 3641-08-5

  • Cat. No. CS-W021700
  • Purity≥97%
  • MDL No.MFCD03990481

*For research and further manufacturing use only, not for direct human use.

H-1,2,4-Triazole-3-carboxamide|CS-W021700

Structure of 3641-08-5

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General Information

  • CAS No. 3641-08-5
  • Cat. No. CS-W021700
  • Purity ≥97%
  • MDL No. MFCD03990481
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃H₄N₄O
  • Molecular Weight 112.09
  • Synonym(s) None
  • SMILES NC(C1=NN=CN1)=O

Description

C6(6-azido) Ceramide, also known as N-(6-azidohexanoyl)-D-erythro-sphingosine, is a head group modified lipid. This click reagent contains an azide group in the omega-terminal end, which can be used in a copper-catalyzed azidealkyne click chemistry. Copper-catalyzed azidealkyne cycloaddition reaction facilitates the connection of molecular entities of all sizes.

Application

2H-1,2,4-Triazole-3-carboxamide serves as a versatile heterocyclic building block in medicinal and synthetic chemistry, enabling the construction of bioactive scaffolds through well-established functional group transformations. Its amide functionality provides enhanced solubility and hydrogen-bonding capacity, while the triazole ring offers metabolic stability and favorable binding interactions. The compound exhibits excellent bench stability and compatibility with standard coupling protocols, facilitating efficient synthesis of complex molecules.

Synthesis

  • Route1

    References

    • Seism, Robert A.; Stec, Donald F.; Bachmann, Brian O. Organic Letters, 2007 , vol. 9, # 21 p. 4179 - 4182
  • Route2

    References

    • Antimicrobial Agents and Chemotherapy, , vol. 48, # 10 p. 4006 - 4008

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   84.66
  • LogP   -1.0964
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   1

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