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Structure of 364047-51-8
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This isouronium reagent features a pyridinone-bearing electrophilic center paired with a hexafluorophosphate counterion, enabling efficient coupling under mild conditions. The tetramethyl substitution enhances solubility and stability, while the 2-oxopyridin-1(2H)-yl group facilitates rapid reaction kinetics in amide bond formation.
1,1,3,3-Tetramethyl-2-(2-oxopyridin-1(2H)-yl)isouronium hexafluorophosphate serves as a highly effective reagent for amide and peptide bond formation under mild conditions. Its pyridone-based isourea structure enables rapid coupling with carboxylic acids, offering excellent functional group tolerance and clean byproduct formation. The reagent exhibits superior bench stability and ease of purification, making it well-suited for high-throughput synthesis and scale-up in medicinal chemistry and process development workflows.
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GHS Pictogram :
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GHS No : GHS05,GHS07
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Signal Word : Danger
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UN#: 1759
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Class : 8
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Packing Group : Ⅲ
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Hazard Statements : H302-H314
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Precautionary Statements : P260-P264-P270-P280-P301+P330+P331-P304+P340-P330-P363-P405-P501
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Lot numbers can be found on the outside label of a product: