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CS-W001157 4
Total: USD 88.00

(4'-Chloro-[1,1'-biphenyl]-4-yl)boronic acid

  • CAS No. 364044-44-0

  • Cat. No. CS-W000918
  • Purity≥97%
  • MDL No.MFCD08544389

*For research and further manufacturing use only, not for direct human use.

(4'-Chloro-[1,1'-biphenyl]-4-yl)boronic acid|CS-W000918

Structure of 364044-44-0

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General Information

  • CAS No. 364044-44-0
  • Cat. No. CS-W000918
  • Purity ≥97%
  • MDL No. MFCD08544389
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₀BClO₂
  • Molecular Weight 232.47
  • Synonym(s) boronic acid, B-(4'-chloro[1,1'-biphenyl]-4-yl)-
  • SMILES Clc1ccc(cc1)c1ccc(cc1)B(O)O

Description

This boronate moiety features a para-chlorinated biphenyl scaffold, delivering enhanced stability and compatibility in Suzuki-Miyaura cross-coupling reactions. The electron-deficient arylboronic acid enables efficient C–C bond formation under standard conditions, offering predictable reactivity and ease of handling for synthetic chemists developing functionalized biaryl architectures.

Application

(4'-Chloro-[1,1'-biphenyl]-4-yl)boronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling efficient construction of biaryl scaffolds. Its chlorinated aryl group offers orthogonal reactivity for sequential functionalization, while the boronic acid moiety ensures excellent stability and ease of purification. This compound facilitates the synthesis of complex heterocycles and pharmaceutical intermediates with high fidelity under standard reaction conditions.

Synthesis

  • Route1
    • null|null
      121-43-7
    • null|null
      67000-01-5
    • In-stock
      4-Bromo-4'-chloro-1,1'-biphenyl|CS-0148348
      23055-77-8
    • ~%
    • In-stock
      (4'-Chloro-[1,1'-biphenyl]-4-yl)boronic acid|CS-W000918
      364044-44-0

    References

    • US2002/142108 A1, ;
  • Route2

    References

    • WO2006/120859 A1, ; Page/Page column 55 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   40.46
  • LogP   1.6868
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   2

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