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CS-W001157 4
Total: USD 88.00

2-(Trifluoromethyl)benzene-1,4-diamine

  • CAS No. 364-13-6

  • Cat. No. CS-W017414
  • Purity≥98%
  • MDL No.MFCD00036101

*For research and further manufacturing use only, not for direct human use.

2-(Trifluoromethyl)benzene-1,4-diamine|CS-W017414

Structure of 364-13-6

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General Information

  • CAS No. 364-13-6
  • Cat. No. CS-W017414
  • Purity ≥98%
  • MDL No. MFCD00036101
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇F₃N₂
  • Molecular Weight 176.14
  • Synonym(s) IFLAB-BB F2108-0128
  • SMILES NC1=CC=C(N)C=C1C(F)(F)F

Description

2-(Trifluoromethyl)benzene-1,4-diamine features a para-substituted aromatic core bearing both an electron-withdrawing trifluoromethyl group and two primary amine functionalities. This combination imparts enhanced solubility and stability under standard conditions, enabling direct use in coupling reactions and as a building block for functionalized polymers and bioactive molecules.

Application

2-(Trifluoromethyl)benzene-1,4-diamine serves as a valuable building block in medicinal chemistry and materials science, enabling the synthesis of heterocyclic scaffolds and functionalized aromatic systems. Its dual primary amine functionality exhibits excellent compatibility with standard coupling reactions, including amidations, reductive aminations, and electrophilic substitutions. The trifluoromethyl group imparts enhanced metabolic stability and lipophilicity, making it particularly useful in drug discovery campaigns targeting CNS and oncology indications. Bench-stable and readily purified by recrystallization, it facilitates scalable synthesis and integration into multi-step sequences.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   52.04
  • LogP   1.8698
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   0

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