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CS-W001157 4
Total: USD 88.00

3,5-Difluoro-4-methoxyaniline

  • CAS No. 363-47-3

  • Cat. No. CS-W017952
  • Purity≥97%
  • MDL No.MFCD04115910

*For research and further manufacturing use only, not for direct human use.

3,5-Difluoro-4-methoxyaniline|CS-W017952

Structure of 363-47-3

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General Information

  • CAS No. 363-47-3
  • Cat. No. CS-W017952
  • Purity ≥97%
  • MDL No. MFCD04115910
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇F₂NO
  • Molecular Weight 159.13
  • Synonym(s) p-Anisidine, 3,5-difluoro-
  • SMILES NC1=CC(F)=C(OC)C(F)=C1

Description

3,5-Difluoro-4-methoxyaniline features a fluorinated aromatic core with complementary electron-donating and withdrawing substituents. This arrangement enhances solubility in polar organic media while maintaining stability under standard bench conditions. The molecule integrates readily into pharmaceutical intermediates and functional materials, offering precise tuning of electronic properties through its orthogonal substitution pattern.

Application

3,5-Difluoro-4-methoxyaniline serves as a valuable building block in medicinal chemistry, enabling the synthesis of fluorinated aromatic scaffolds through standard coupling reactions. Its ortho-fluoro substituents facilitate subsequent C–H functionalization, while the methoxy group offers moderate electron-donating character and enhanced solubility. The compound exhibits good bench stability and is compatible with common protecting group strategies, facilitating downstream transformations in API development workflows.

Synthesis

  • Route1

    References

    • Qiu, Jian; Stevenson, Scott H.; O'Beirne, Michael J.; Silverman, Richard B. Journal of Medicinal Chemistry, 1999 , vol. 42, # 2 p. 329 - 332
  • Route2

    References

    • Journal of Medicinal Chemistry, , vol. 42, # 2 p. 329 - 332
  • Route3

    References

    • Journal of Medicinal Chemistry, , vol. 42, # 2 p. 329 - 332

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   35.25
  • LogP   1.5556
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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