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tert-Butyl 2-hydroxy-2-methylpropanoate

  • CAS No. 36293-63-7

  • Cat. No. CS-0227378
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

tert-Butyl 2-hydroxy-2-methylpropanoate|CS-0227378

Structure of 36293-63-7

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General Information

  • CAS No. 36293-63-7
  • Cat. No. CS-0227378
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₆O₃
  • Molecular Weight 160.21
  • Synonym(s) TERT-BUTYL ALPHA-HYDROXYISOBUTYRATE
  • SMILES CC(C)(O)C(OC(C)(C)C)=O

Description

tert-Butyl 2-hydroxy-2-methylpropanoate features a sterically hindered tertiary alcohol moiety that enhances stability under acidic conditions. This bench-stable ester serves as a protected hydroxy precursor in synthetic sequences, enabling controlled deprotection and functional group interconversions. The tert-butyl group facilitates efficient isolation and purification, while the alpha-hydroxy functionality supports downstream derivatization in complex molecule assembly.

Application

tert-Butyl 2-hydroxy-2-methylpropanoate serves as a stable, bench-friendly building block for the synthesis of α-hydroxy carboxylic acid derivatives. Its tertiary ester functionality enables selective hydrolysis under mild acidic conditions, facilitating access to the corresponding carboxylic acid with retained stereochemical integrity. The molecule exhibits excellent functional group tolerance and simplifies purification due to its low polarity and high crystallinity, making it well-suited for use in iterative synthetic sequences and complex molecule assembly.

Safety Information

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GHS Pictogram :
GHS No : GHS02
Signal Word : Danger
UN#: 3272
Class : 3
Packing Group : Ⅲ
Hazard Statements : H226
Precautionary Statements : P210-P233-P240-P241-P242-P243-P280-P370+P378-P501

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Computational Chemistry Data

  • TPSA   46.53
  • LogP   1.099
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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