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CS-W001157 4
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3-Bromo-2-fluoropyridine

  • CAS No. 36178-05-9

  • Cat. No. CS-D0935
  • Purity≥97%
  • MDL No.MFCD04112496

*For research and further manufacturing use only, not for direct human use.

3-Bromo-2-fluoropyridine|CS-D0935

Structure of 36178-05-9

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General Information

  • CAS No. 36178-05-9
  • Cat. No. CS-D0935
  • Purity ≥97%
  • MDL No. MFCD04112496
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃BrFN
  • Molecular Weight 175.99
  • Synonym(s) 2-Fluoro-3-Bromopyridine
  • SMILES FC1=NC=CC=C1Br

Description

3-Bromo-2-fluoropyridine is a fluorinated heterocyclic building block featuring complementary halogen handles for cross-coupling. The ortho-fluoro and bromo substituents enable sequential functionalization, facilitating access to complex pyridine derivatives in medicinal chemistry and materials science. This bench-stable reagent integrates readily into Suzuki, Stille, and Negishi transformations under standard conditions.

Application

3-Bromo-2-fluoropyridine serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling palladium-catalyzed cross-coupling reactions due to its orthogonal halogen reactivity. The bromo group facilitates efficient C–C bond formation, while the fluorine substituent enhances metabolic stability and modulates electronic properties. Its bench-stable nature and compatibility with common reaction conditions make it a practical choice for constructing complex heterocyclic scaffolds.

Safety Information

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GHS Pictogram :
GHS No : GHS05,GHS06
Signal Word : Danger
UN#: 2810
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H302-H310-H315-H318-H335
Precautionary Statements : P261-P262-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P361+P364-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   1.9832
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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