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CS-W001157 4
Total: USD 88.00

Cyclopropyl(4-hydroxyphenyl)methanone

  • CAS No. 36116-18-4

  • Cat. No. CS-0103541
  • Purity≥98%
  • MDL No.MFCD06200217

*For research and further manufacturing use only, not for direct human use.

Cyclopropyl(4-hydroxyphenyl)methanone|CS-0103541

Structure of 36116-18-4

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General Information

  • CAS No. 36116-18-4
  • Cat. No. CS-0103541
  • Purity ≥98%
  • MDL No. MFCD06200217
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₀O₂
  • Molecular Weight 162.19
  • Synonym(s) Cyclopropy(4-hydroxyphenyl)Methanone
  • SMILES O=C(C1CC1)C2=CC=C(O)C=C2

Description

Cyclopropyl(4-hydroxyphenyl)methanone features a cyclopropyl group attached to a carbonyl-linked 4-hydroxyphenyl moiety, combining steric rigidity with phenolic hydroxyl reactivity. This scaffold integrates readily into bioactive molecules, offering enhanced metabolic stability and tunable solubility for medicinal chemistry applications.

Application

Cyclopropyl(4-hydroxyphenyl)methanone serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive aryl ketones and heterocyclic scaffolds. The molecule combines a stable cyclopropyl group with a phenolic hydroxyl, offering enhanced metabolic stability and favorable lipophilicity for drug discovery applications. It participates reliably in standard coupling reactions and functional group interconversions, facilitating efficient access to complex molecular architectures.

Synthesis

  • Route1
    • 4-Chloro-1-(4-hydroxyphenyl)butan-1-one|CS-W006588
      7150-55-2
    • ~96%
    • In-stock
      Cyclopropyl(4-hydroxyphenyl)methanone|CS-0103541
      36116-18-4

    References

    • Chang, Sou-Jen; Fernando, Dilinie P.; King, Steve Organic Process Research and Development, 2001 , vol. 5, # 2 p. 141 - 143
  • Route2

    References

    • Novo Nordisk A/S Patent: US6908926 B1, 2005 ; Location in patent: Page/Page column 42-44 ; US 6908926 B1
  • Route3
    • 4-Chloro-1-(4-hydroxyphenyl)butan-1-one|CS-W006588
      7150-55-2
    • ~63%
    • In-stock
      Cyclopropyl(4-hydroxyphenyl)methanone|CS-0103541
      36116-18-4
    • null|null
      113425-33-5

    References

    • Chang, Sou-Jen; Fernando, Dilinie P.; King, Steve Organic Process Research and Development, 2001 , vol. 5, # 2 p. 141 - 143

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   1.9849
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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