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CS-W001157 4
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5-Bromo-6-chloropyridin-2-amine

  • CAS No. 358672-65-8

  • Cat. No. CS-W003809
  • Purity≥97%
  • MDL No.MFCD11848481

*For research and further manufacturing use only, not for direct human use.

5-Bromo-6-chloropyridin-2-amine|CS-W003809

Structure of 358672-65-8

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General Information

  • CAS No. 358672-65-8
  • Cat. No. CS-W003809
  • Purity ≥97%
  • MDL No. MFCD11848481
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₄BrClN₂
  • Molecular Weight 207.46
  • Synonym(s) 6-Amino-2-chloro-3-bromopyridine
  • SMILES Nc1ccc(c(n1)Cl)Br

Description

5-Bromo-6-chloropyridin-2-amine serves as a critical heterocyclic building block for medicinal chemistry and agrochemical synthesis. The molecule features a pyridine core functionalized with bromo and chloro substituents at electron-deficient positions, enabling selective cross-coupling reactions. This combination delivers enhanced reactivity in palladium-catalyzed transformations while maintaining bench-stable handling characteristics under standard conditions.

Application

5-Bromo-6-chloropyridin-2-amine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its orthogonal halogen reactivity. The bromo and chloro substituents allow sequential functionalization, while the pyridin-2-amine moiety provides a handle for further derivatization via amide formation or metal coordination. Its bench-stable crystalline form facilitates handling and purification, making it well-suited for scalable synthesis of heterocyclic scaffolds in API development.

Safety Information

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GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301
Precautionary Statements : P264-P270-P330-P405-P501

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   2.0797
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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