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Structure of 35852-81-4
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4-Chloro-1-methyl-1H-pyrazole is a bench-stable heterocyclic scaffold featuring a chlorine substituent at the 4-position and a methyl group at nitrogen-1. This electron-deficient pyrazole integrates readily into medicinal chemistry libraries, serving as a bioisostere for phenyl rings and enabling enhanced metabolic stability in lead compounds.
4-Chloro-1-methyl-1H-pyrazole serves as a versatile building block in medicinal chemistry, enabling efficient access to substituted pyrazole scaffolds through palladium-catalyzed cross-coupling reactions. Its chlorine atom facilitates nucleophilic substitution and coupling with arylboranes, while the methyl group enhances solubility and metabolic stability. The compound exhibits good bench stability and is readily purified by flash chromatography, making it well-suited for iterative synthesis of bioactive molecules.
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GHS Pictogram :
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GHS No : GHS02,GHS07
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Signal Word : Danger
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UN#: 1993
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Class : 3
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Packing Group : Ⅲ
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Hazard Statements : H226-H315-H319-H335
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Precautionary Statements : P210-P233-P240-P241-P242-P243-P280-P303+P361+P353-P370+P378-P403+P235-P501
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Lot numbers can be found on the outside label of a product: