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CS-W001157 4
Total: USD 88.00

2-Bromo-4-fluoropyridine

  • CAS No. 357927-50-5

  • Cat. No. CS-W003601
  • Purity≥98%
  • MDL No.MFCD09260909

*For research and further manufacturing use only, not for direct human use.

2-Bromo-4-fluoropyridine|CS-W003601

Structure of 357927-50-5

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General Information

  • CAS No. 357927-50-5
  • Cat. No. CS-W003601
  • Purity ≥98%
  • MDL No. MFCD09260909
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃BrFN
  • Molecular Weight 175.99
  • Synonym(s) None
  • SMILES FC1=CC(Br)=NC=C1

Description

2-Bromo-4-fluoropyridine is a halogenated pyridine derivative featuring complementary electrophilic and nucleophilic sites. This bench-stable heterocycle enables direct functionalization in cross-coupling and C–H activation reactions, serving as a key building block for pharmaceutical intermediates and agrochemicals.

Application

2-Bromo-4-fluoropyridine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its orthogonal halogen reactivity. The bromine center facilitates efficient C–C bond formation, while the fluorine substituent enhances metabolic stability and modulates electronic properties. Its bench-stable nature and compatibility with diverse reaction conditions make it well-suited for constructing complex heterocyclic scaffolds in API development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 1760
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H318
Precautionary Statements : P264-P270-P280-P280-P501

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   1.9832
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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