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CS-W001157 4
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Fmoc-DL-Ala-OH

  • CAS No. 35661-38-2

  • Cat. No. CS-0045006
  • Purity≥98%
  • MDL No.MFCD01456463

*For research and further manufacturing use only, not for direct human use.

Fmoc-DL-Ala-OH|CS-0045006

Structure of 35661-38-2

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General Information

  • CAS No. 35661-38-2
  • Cat. No. CS-0045006
  • Purity ≥98%
  • MDL No. MFCD01456463
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₈H₁₇NO₄
  • Molecular Weight 311.33
  • Synonym(s) FMOC-DL-Alanine
  • SMILES CC(C(O)=O)NC(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O

Description

Fmoc-DL-Ala-OH is a protected alanine derivative featuring a fluorenylmethoxy carbonyl (Fmoc) group for orthogonal peptide synthesis. This bench-stable, moisture-tolerant building block facilitates efficient coupling in solid-phase peptide elongation workflows.

Application

Fmoc-DL-Ala-OH serves as a key building block in solid-phase peptide synthesis, offering robust protection of the amine group and facile deprotection under mild basic conditions. Its benzyloxycarbonyl-like stability enables reliable coupling to growing peptide chains, while the side-chain carboxylate remains unmodified for orthogonal functionalization. The compound demonstrates excellent bench stability, minimal racemization during activation, and compatibility with standard Fmoc protocols across diverse synthetic workflows.

Synthesis

  • Route1
    • null|null
      909114-66-5
    • In-stock
      DL-Alanine|CS-0022544
      302-72-7
    • ~97%
    • In-stock
      Fmoc-DL-Ala-OH|CS-0045006
      35661-38-2

    References

    • Hioki, Kazuhito; Kinugasa, Mizuho; Kishimoto, Michiko; Fujiwara, Miho; Tani, Shohei; Kunishima, Munetaka Synthesis, 2006 , # 12 p. 1931 - 1933
  • Route2

    References

    • Chen, Laizhong; Sun, Wei; Li, Jing; Liu, Zhenzhen; Ma, Zhao; Zhang, Wei; Du, Lupei; Xu, Wenfang; Fang, Hao; Li, Minyong Organic and Biomolecular Chemistry, 2013 , vol. 11, # 2 p. 378 - 382
  • Route3
    • null|null
      71953-00-9
    • ~97%
    • In-stock
      Fmoc-DL-Ala-OH|CS-0045006
      35661-38-2

    References

    • Sridhar, P. Ramu; Sinha, Surajit; Chandrasekaran Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2002 , vol. 41, # 1 p. 157 - 160

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

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Computational Chemistry Data

  • TPSA   75.63
  • LogP   2.9982
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   4

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