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CS-W001157 4
Total: USD 88.00

10,11-Dihydrocarbamazepine

  • CAS No. 3564-73-6

  • Cat. No. CS-0020282
  • Purity≥97%
  • MDL No.MFCD00005072

*For research and further manufacturing use only, not for direct human use.

10,11-Dihydrocarbamazepine|CS-0020282

Structure of 3564-73-6

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General Information

  • CAS No. 3564-73-6
  • Cat. No. CS-0020282
  • Purity ≥97%
  • MDL No. MFCD00005072
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₅H₁₄N₂O
  • Molecular Weight 238.28
  • Synonym(s) None
  • SMILES O=C(N1C2=CC=CC=C2CCC3=CC=CC=C31)N

Description

10,11-Dihydrocarbamazepine is an impurity present in dibenzazepine drug used in the treatment of epilepsy. Single-crystal structure of new dimer-based polymorph of 10,11-dihydrocarbamazepine has been investigated.10,11-Dihydrocarbamazepine was used as internal standard during simultaneous determination of carbamazepine and its active metabolite in plasma by liquid chromatography. It was used in chemiluminescence method for determination of carbamazepine.

Application

10,11-Dihydrocarbamazepine serves as a key intermediate in the synthesis of carbamazepine and related anticonvulsant scaffolds. Its stable dihydro structure facilitates selective functionalization at the 10- and 11-positions, enabling efficient access to substituted iminostilbenes and heterocyclic analogs via standard coupling and cyclization protocols. The compound exhibits good bench stability and compatibility with common protecting group strategies, making it a practical building block for medicinal chemistry campaigns targeting CNS therapeutics.

Synthesis

  • Route1
    • null|null
      33948-19-5
    • ~84%
    • In-stock
      10,11-Dihydrocarbamazepine|CS-0020282
      3564-73-6

    References

    • Shamshin, V. P.; Voronin, V. G.; Borisov, M. M.; Mufazalova, T. P. Pharmaceutical Chemistry Journal, 1987 , vol. 21, # 6 p. 443 - 448 Khimiko-Farmatsevticheskii Zhurnal, 1987 , vol. 21, # 6 p. 711 - 716
  • Route2
    • Carbamazepine Oxcarbazepine Impurity|CS-0228809
      298-46-4
    • ~85%
    • In-stock
      10,11-Dihydrocarbamazepine|CS-0020282
      3564-73-6

    References

    • Dunnbier; Jugelt Pharmazie, 1991 , vol. 46, # 7 p. 512 - 517
  • Route3

    References

    • Pharmaceutical Chemistry Journal, , vol. 21, # 6 p. 443 - 448 Khimiko-Farmatsevticheskii Zhurnal, , vol. 21, # 6 p. 711 - 716

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07,GHS08
Signal Word : Danger
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H317-H336-H360-H402
Precautionary Statements : P261-P264-P270-P271-P272-P273-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   46.33
  • LogP   3.002
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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