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CS-W001157 4
Total: USD 88.00

(Z)-Sunitinib carboxylic acid

  • CAS No. 356068-93-4

  • Cat. No. CS-M1922
  • Purity≥95%
  • MDL No.MFCD11521323

*For research and further manufacturing use only, not for direct human use.

(Z)-Sunitinib carboxylic acid|CS-M1922

Structure of 356068-93-4

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General Information

  • CAS No. 356068-93-4
  • Cat. No. CS-M1922
  • Purity ≥95%
  • MDL No. MFCD11521323
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₆H₁₃FN₂O₃
  • Molecular Weight 300.28
  • Synonym(s) None
  • SMILES O=C(NC1=C/2C=C(F)C=C1)C2=C/C3=C(C)C(C(O)=O)=C(C)N3

Description

This (Z)-configured pyrrole derivative features a fluorinated oxindole moiety linked via a methylidene bridge, delivering enhanced stability and targeted reactivity. The electron-deficient pyrrole core, combined with sterically hindered methyl groups, enables selective conjugation in synthetic and medicinal chemistry applications.

Application

(Z)-5-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid serves as a versatile building block for the synthesis of fluorinated indoline-containing heterocycles. Its conjugated enone system enables efficient Michael additions and cycloaddition reactions, while the carboxylic acid group facilitates direct derivatization or salt formation. The molecule exhibits bench stability and compatibility with standard purification methods, making it suitable for iterative synthetic workflows in medicinal chemistry and process development.

Synthesis

  • Route1

    References

    • SCINOPHARM TAIWAN, LTD.; Henscheke, Julian P.; Chen, Yung-Fa Patent: US2013/190512 A1, 2013 ; Location in patent: Paragraph 0088 ;
  • Route2

    References

    • Tang, Peng Cho; Miller, Todd A.; Li, Xiaoyuan; Sun, Li; Wei, Chung Chen; Shirazian, Shahrzad; Liang, Congxin; Vojkovsky, Tomas; Nematalla, Asaad S.; Hawley, Michael Patent: US2002/156292 A1, 2002 ;
  • Route3
    • In-stock
      5-Formyl-2,4-dimethylpyrrole-3-carboxylic acid|CS-W003265
      253870-02-9
    • null|null
      1374685-40-1
    • ~97%
    • In-stock
      (Z)-Sunitinib carboxylic acid|CS-M1922
      356068-93-4

    References

    • SCINOPHARM TAIWAN, LTD.; Henscheke, Julian P.; Chen, Yung-Fa Patent: US2013/190512 A1, 2013 ; Location in patent: Paragraph 0087 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   82.19
  • LogP   2.96154
  • H_Acceptors   2
  • H_Donors   3
  • Rotatable_Bonds   2

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