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CS-W001157 4
Total: USD 88.00

5-Bromonicotinonitrile

  • CAS No. 35590-37-5

  • Cat. No. CS-W002478
  • Purity≥98%
  • MDL No.MFCD00174363

*For research and further manufacturing use only, not for direct human use.

5-Bromonicotinonitrile|CS-W002478

Structure of 35590-37-5

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General Information

  • CAS No. 35590-37-5
  • Cat. No. CS-W002478
  • Purity ≥98%
  • MDL No. MFCD00174363
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₃BrN₂
  • Molecular Weight 183.01
  • Synonym(s) 5-bromopyridine-3-carbonitrile
  • SMILES Brc1cc(cnc1)C#N

Description

5-Bromonicotinonitrile features a bromine substituent at the pyridine ring's 5-position and a nitrile group at the 3-position, enabling efficient cross-coupling reactions. This electron-deficient heterocycle integrates readily into pharmaceutical intermediates and functional materials, offering enhanced reactivity under standard conditions.

Application

5-Bromonicotinonitrile serves as a versatile building block in synthetic organic chemistry, enabling palladium-catalyzed cross-coupling reactions to construct biaryl scaffolds. The nitrile group provides a handle for selective transformations, while the bromine substituent offers high reactivity in Suzuki, Stille, and Negishi couplings. Its bench-stable nature and compatibility with diverse functional groups make it a practical choice for medicinal chemistry and process development workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501

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Computational Chemistry Data

  • TPSA   36.68
  • LogP   1.71578
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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