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CS-W001157 4
Total: USD 88.00

2,4-Dimethoxypyrimidine

  • CAS No. 3551-55-1

  • Cat. No. CS-W016466
  • Purity≥98%
  • MDL No.MFCD00056028

*For research and further manufacturing use only, not for direct human use.

2,4-Dimethoxypyrimidine|CS-W016466

Structure of 3551-55-1

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General Information

  • CAS No. 3551-55-1
  • Cat. No. CS-W016466
  • Purity ≥98%
  • MDL No. MFCD00056028
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₈N₂O₂
  • Molecular Weight 140.14
  • Synonym(s) 2,4-Dimethoxyprimidine
  • SMILES C1=NC(=NC(=C1)OC)OC

Description

2,4-Dimethoxypyrimidine serves as a key heterocyclic scaffold in medicinal chemistry, featuring two methoxy groups that enhance solubility and modulate electronic properties. This bench-stable compound integrates readily into kinase inhibitors and antiviral agents, offering predictable reactivity in nucleophilic substitution and cross-coupling transformations under standard conditions.

Application

2,4-Dimethoxypyrimidine serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient construction of heterocyclic scaffolds. Its two methoxy groups provide orthogonal reactivity for selective functionalization, while the pyrimidine core offers excellent stability and compatibility with standard coupling conditions. The compound facilitates direct substitution at C5 and subsequent derivatization, making it particularly valuable for accessing substituted pyrimidines via palladium-catalyzed cross-coupling or nucleophilic displacement reactions.

Synthesis

  • Route1
    • In-stock
      5-Bromo-2,4-dimethoxypyrimidine|CS-W014776
      56686-16-9
    • null|null
      176643-32-6
    • ~39%
    • In-stock
      2,4-Dimethoxypyrimidine|CS-W016466
      3551-55-1
    • null|null
      1017841-99-4

    References

    • Tetrahedron Letters, , vol. 52, # 16 p. 1866 - 1870
  • Route2
    • In-stock
      5-Bromo-2,4-dimethoxypyrimidine|CS-W014776
      56686-16-9
    • null|null
      176643-32-6
    • ~70%
    • In-stock
      2,4-Dimethoxypyrimidine|CS-W016466
      3551-55-1
    • null|null
      1017841-99-4
    • null|null
      1294479-78-9

    References

    • Tetrahedron Letters, , vol. 52, # 16 p. 1866 - 1870
  • Route3
    • null|null
      3934-20-1
    • null|null
      141-52-6
    • ~80%
    • In-stock
      2,4-Dimethoxypyrimidine|CS-W016466
      3551-55-1

    References

    • Marzilli,L.; Decastro,B.; Caradonna,J.P. Journal of the American Chemical Society, 1980 , vol. 102, p. 916

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   44.24
  • LogP   0.4938
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   2

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