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Structure of 354814-19-0
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This trifluoromethyl-substituted benzonitrile features a strategically positioned amino group enabling direct functionalization in synthetic sequences. The electron-deficient aromatic ring enhances reactivity in transition-metal-catalyzed couplings, while the nitrile and amine moieties offer orthogonal handles for downstream derivatization. Bench-stable and moisture-tolerant, it integrates efficiently into complex molecular architectures.
5-Amino-2-(trifluoromethyl)benzonitrile serves as a versatile building block in medicinal chemistry, enabling the synthesis of heterocyclic scaffolds via cyclization reactions. Its amino and nitrile groups offer orthogonal reactivity for downstream functionalization, while the trifluoromethyl group enhances metabolic stability and lipophilicity. The compound exhibits good bench stability and is amenable to standard purification techniques, facilitating integration into multi-step synthetic sequences.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: